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Core Bioinformatics group


Methods papers


ClustAssess: tools for assessing the robustness of single-cell clustering
Arash Shahsavari, Andi Munteanu, Irina Mohorianu

bulkAnalyseR: An accessible, interactive pipeline for analysing and sharing bulk multi-modal sequencing data
Ilias Moutsopoulos*, Eleanor C Williams*, Irina Mohorianu (2022); Briefings in Bioinformatics


The sum of two halves may be different from the whole. Effects of splitting sequencing samples across lanes.
Eleanor C Williams*, Ruben Chazarra-Gil*, Arash Shahsavari*, Irina Mohorianu (2022) Genes

noisyR: Enhancing biological signal in sequencing datasets by characterising random technical noise
I. Moutsopoulos, L. Maischak, E. Lauzikaite, S. A. Vasquez Urbina, E. C. Williams, H. G. Drost, I. Mohorianu


feamiR: Feature selection based on Genetic Algorithms for predicting miRNA-mRNA interactions
Eleanor C. Williams, Anisoara Calinescu, Irina Mohorianu

Publications in collaboration with CSCI PIs


Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
H Bulstrode, G C. Girdler, T Gracia, A Aivazidis, I Moutsopoulos, A M.H. Young, J Hancock, X He, K Ridley, Z Xu, J H. Stockley, J Finlay, C Hallou, T Fajardo, D M.Fountain, S Dongen, A Joannides, R Morris, R Mair, C Watts, T Santarius, SJ. Price, P J.A. Hutchinson, E J. Hodson, S M. Pollard, I Mohorianu, R A.Barker, T R. Sweeney, O Bayraktar, F Gergely, D H.Rowitch

Host Respiratory Transcriptome Signature Associated with Poor Outcome in Children with Influenza–Staphylococcus aureus Pneumonia
Carl Britto*, Irina Mohorianu*, ... Adrienne G Randolph, Kristin L Moffitt

Chronic injury induces plasticity between cholangiocytes and hepatocytes in the human liver
Vasileios Galanakis, Christopher Gribben, Alexander Calderwood, Ilias Moutsopoulos,... , Irina Mohorianu*, Ludovic Vallier*

RBPMS promotes contractile smooth muscle splicing and alters phenotypic behaviour of human embryonic stem cell derived vascular smooth muscle cells.
Aishwarya G Jacob, Ilias Moutsopoulos, Alexander Petchey, Irina Mohorianu*, Sanjay Sinha*, Chris Smith*

Patterns of oncogene co-expression at single cell resolution in cancer influence survival
Michal Marek Hoppe, Patrick Jaynes, ... Ilias Moutsopoulos, Irina Mohorianu, Daniel J Hodson, ... Claudio Tripodo, Anand D Jeyasekharan


Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells
Moyra Lawrence, Arash Shahsavari, Susanne Bornelöv, Thomas Moreau, Katarzyna Kania, Maike Paramor, Rebecca McDonald, James Baye, Marion Perrin, Maike Steindel, Paula Jimenez-Gomez, Christopher Penfold, Irina Mohorianu, Cedric Ghevaert

NOTCH1 drives immune-escape mechanisms in B cell malignancies
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsoupoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D’Santos, Silvia Deaglio, Jose I. Martin-Subero, Ingo Ringshausen

ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia
Jingyu Chen, Vijitha Sathiaseelan, Andrew Moore, Shengjiang Tan, Chandra Sekkar Reddy Chilamakuri, Valar Nila Roamio Franklin, Arash Shahsavari, Constanze Jakwerth, Sandra B. Hake, Alan J. Warren, Irina Mohorianu, Clive D’Santos, Ingo Ringshausen

Defining the transcriptional signature of esophageal-to-skin lineage conversion
Maria T. Bejar, Paula Jimenez-Gomez, Ilias Moutsopoulos, Bartomeu Colom, Seungmin Han, Fernando J Calero-Nieto, Berthold Göttgens, Irina Mohorianu, Benjamin D. Simons, Maria P. Alcolea


Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Anna Maria Ranzoni, Andrea Tangherloni, Ivan Berest, Simone G Riva, Brynelle Myers, Paulina M. Strzelecka, Jiarui Xu, Elisa Panada, Irina Mohorianu, Judith B. Zaugg, Ana Cvejic

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
S Basu, O Shukron,  A Ponjavic, P Parruto, W Boucher, W Zhang, N Reynolds, D Lando, D Shah, LH Sober, A Jartseva,  R Ragheb, J Cramard, R Floyd, G Brown, K Gor, J Balmer, TA Drury, AR Carr,  L-M Needham, A Aubert, G Communie, L Morey,  E Blanco, MA Barber, I Mohorianu, T Bartke,  L Di Croce,  I Berger,  C Schaffitzel,  SF Lee, TJ Stevens,  D Klenerman,  BD Hendrich,  D Holcman,  ED Laue


The truth is rarely pure and never simple. Oscar Wilde, The Importance of Being Earnest